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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TP53 mRNA; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TP53 mRNA]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TP53 mRNA]PMID:31542844 PMID:32402895
Tp53affects expressionISOTP53 (Homo sapiens)6480464CTDArsenic affects the expression of TP53 mRNA; Arsenic affects the expression of TP53 proteinPMID:17450239 PMID:18414638
Tp53affects localizationISOTrp53 (Mus musculus)6480464CTDArsenic affects the localization of TRP53 proteinPMID:27289040
Tp53affects response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 polymorphism affects the susceptibility to ArsenicPMID:21982800
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDArsenic results in decreased expression of TP53 mRNA; Arsenic results in decreased expression of TP53 proteinPMID:19945496 PMID:28785074
Tp53decreases methylationISOTP53 (Homo sapiens)6480464CTDArsenic results in decreased methylation of TP53 exonPMID:21756780
Tp53decreases phosphorylationISOTP53 (Homo sapiens)6480464CTDArsenic results in decreased phosphorylation of TP53 proteinPMID:24473091
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDArsenic results in increased expression of TP53 mRNA; Arsenic results in increased expression of TP53 protein; Arsenic results in increased expression of TP53 protein mutant formPMID:12899209 PMID:23174854 PMID:27122327 PMID:34998823
Tp53increases methylationISOTP53 (Homo sapiens)6480464CTDArsenic results in increased methylation of TP53 promoterPMID:16251483 PMID:21756780
Tp53increases mutagenesisISOTP53 (Homo sapiens)6480464CTDArsenic results in increased mutagenesis of TP53 exon; Arsenic results in increased mutagenesis of TP53 genePMID:15967209 PMID:17450239 PMID:21756780 PMID:26772154 PMID:34998823
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 gene mutant form results in increased susceptibility to Arsenic; TP53 gene polymorphism results in increased susceptibility to ArsenicPMID:16930632 PMID:23643801
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of TRP53 mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TRP53 mRNA; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TRP53 mRNA]PMID:35714946
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[UNG protein affects the susceptibility to Arsenic] which affects the expression of TP53 protein; APOBEC3B protein affects the reaction [[UNG protein affects the susceptibility to Arsenic] which affects the expression of TP53 protein]; APOBEC3B protein affects the reaction [Arsenic results in increased mutagenesis of TP53 gene]; FTO protein affects the reaction [APOBEC3B protein affects the reaction [Arsenic results in increased mutagenesis of TP53 gene]]; FTO protein affects the reaction [Arsenic results in increased expression of TP53 protein]; YTHDF2 protein affects the reaction [FTO protein affects the reaction [APOBEC3B protein affects the reaction [Arsenic results in increased mutagenesis of TP53 gene]]]PMID:34998823
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