GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of TP53 mRNA; Methotrexate results in increased expression of TP53 protein | PMID:19900424 PMID:29027214 | Tp53 | multiple interactions | EXP | | 6480464 | CTD | Methotrexate results in increased expression of and results in increased phosphorylation of TP53 protein; Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] | PMID:19900424 PMID:35842499 | Tp53 | decreases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Methotrexate results in decreased expression of TP53 mRNA | PMID:17400583 PMID:24449571 | Tp53 | decreases response to substance | ISO | Trp53 (Mus musculus) | 6480464 | CTD | TRP53 mRNA results in decreased susceptibility to Methotrexate; TRP53 protein results in decreased susceptibility to Methotrexate | PMID:16918715 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Methotrexate results in increased expression of TRP53 mRNA | PMID:23836430 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased expression of TP53 mRNA; Methotrexate results in increased expression of TP53 protein | PMID:21624110 PMID:21678067 PMID:22183962 PMID:24967384 PMID:29027214 | Tp53 | increases response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 mutant form results in increased susceptibility to Methotrexate; TP53 protein results in increased susceptibility to Methotrexate | PMID:19548002 PMID:21875941 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of TP53 protein]; BRCA1 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Methotrexate]; ESRRA protein inhibits the reaction [Methotrexate results in increased expression of TP53 protein]; Folic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 mRNA]; MAPK9 gene mutant form inhibits the reaction [Methotrexate results in increased expression of TP53 protein]; Methotrexate inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; Methotrexate results in increased phosphorylation of and results in increased acetylation of and results in increased stability of TP53 protein; nutlin 3 promotes the reaction [Methotrexate results in increased expression of TP53 protein]; sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein]; TP53 affects the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]; TP53 affects the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 protein inhibits the reaction [Methotrexate results in increased expression of CCNB1 protein]; TP53 protein promotes the reaction [Methotrexate results in increased expression of CASP8 mRNA]; TP53 protein promotes the reaction [Methotrexate results in increased expression of CASP8 protein]; TP53 protein promotes the reaction [Methotrexate results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Methotrexate results in increased susceptibility to Antineoplastic Agents]; TP53 protein promotes the reaction [Methotrexate results in increased susceptibility to Cyclophosphamide metabolite] | PMID:17637740 PMID:19548002 PMID:21114963 PMID:21624110 PMID:21875941 PMID:22010212 PMID:22183962 PMID:24967384 | | ||||||||||||||||||||||
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