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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTD[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 proteinPMID:19227835 PMID:26612707 PMID:34047412 PMID:34577062
Tp53affects expressionISOTP53 (Homo sapiens)6480464CTDCurcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 proteinPMID:17041101 PMID:24211270
Tp53affects localizationISOTP53 (Homo sapiens)6480464CTDCurcumin affects the localization of TP53 proteinPMID:17332930
Tp53decreases expressionISOTrp53 (Mus musculus)6480464CTDCurcumin results in decreased expression of TP53 proteinPMID:22714040
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDCurcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 proteinPMID:26409325 PMID:30935902 PMID:33582110
Tp53increases acetylationISOTP53 (Homo sapiens)6480464CTDCurcumin results in increased acetylation of TP53 proteinPMID:17332930
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDCurcumin results in increased expression of TRP53 mRNAPMID:25822711
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTD[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 proteinPMID:19944674 PMID:23222814 PMID:25256401 PMID:25644192
Tp53increases phosphorylationISOTP53 (Homo sapiens)6480464CTDCurcumin results in increased phosphorylation of TP53 proteinPMID:17332930 PMID:19020741 PMID:21134073
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein]PMID:21519798 PMID:28681665 PMID:35817260
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]PMID:19020741 PMID:21134073 PMID:23222814 PMID:24664296 PMID:24831732 PMID:27430728 PMID:30935902
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