GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | multiple interactions | EXP | | 6480464 | CTD | [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 protein | PMID:19227835 PMID:26612707 PMID:34047412 PMID:34577062 | Tp53 | affects expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Curcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 protein | PMID:17041101 PMID:24211270 | Tp53 | affects localization | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Curcumin affects the localization of TP53 protein | PMID:17332930 | Tp53 | decreases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Curcumin results in decreased expression of TP53 protein | PMID:22714040 | Tp53 | decreases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Curcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 protein | PMID:26409325 PMID:30935902 PMID:33582110 | Tp53 | increases acetylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Curcumin results in increased acetylation of TP53 protein | PMID:17332930 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Curcumin results in increased expression of TRP53 mRNA | PMID:25822711 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 protein | PMID:19944674 PMID:23222814 PMID:25256401 PMID:25644192 | Tp53 | increases phosphorylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Curcumin results in increased phosphorylation of TP53 protein | PMID:17332930 PMID:19020741 PMID:21134073 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein] | PMID:21519798 PMID:28681665 PMID:35817260 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein] | PMID:19020741 PMID:21134073 PMID:23222814 PMID:24664296 PMID:24831732 PMID:27430728 PMID:30935902 | |
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