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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of TP53 mRNAPMID:23273579
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDMethylcholanthrene promotes the reaction [TRP53 protein binds to ABCB1B promoter]; Methylcholanthrene promotes the reaction [TRP53 protein binds to FMO3 5' UTR]; Methylcholanthrene results in increased expression of and results in increased activity of TRP53 proteinPMID:11096091 PMID:20570689
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