GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects expression | EXP | | 6480464 | CTD | 1-nitropyrene affects the expression of TP53 mRNA | PMID:11201684 | Tp53 | affects localization | ISO | Trp53 (Mus musculus) | 6480464 | CTD | 1-nitropyrene affects the localization of TRP53 protein | PMID:17240030 | Tp53 | affects response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 affects the susceptibility to 1-nitropyrene | PMID:10837373 | Tp53 | decreases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | 1-nitropyrene results in decreased expression of TRP53 mRNA | PMID:11911274 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | 1-nitropyrene results in increased expression of TRP53 mRNA | PMID:10928071 PMID:11911274 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | 1-nitropyrene results in increased expression of TP53 protein; 1-nitropyrene results in increased expression of TP53 protein modified form | PMID:10837373 PMID:22044530 | Tp53 | increases phosphorylation | ISO | Trp53 (Mus musculus) | 6480464 | CTD | 1-nitropyrene results in increased phosphorylation of TRP53 protein | PMID:17240030 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA] | PMID:10837373 PMID:22044530 | | ||||||||||||||||||||||
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