GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects localization | ISO | TP53 (Homo sapiens) | 6480464 | CTD | oxaliplatin affects the localization of TP53 protein modified form | PMID:19735649 | Tp53 | affects response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein affects the susceptibility to oxaliplatin | PMID:15041737 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | oxaliplatin results in increased expression of TP53 protein; oxaliplatin results in increased expression of TP53 protein modified form | PMID:19015155 PMID:19728331 PMID:19735649 PMID:20708607 | Tp53 | increases response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein results in increased susceptibility to oxaliplatin | PMID:16227409 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [Oxaliplatin results in increased expression of TP53 protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of TP53 protein modified form]; Oxaliplatin promotes the reaction [TP53 protein binds to DUT promoter]; Oxaliplatin results in increased phosphorylation of and results in increased activity of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein]; TP53 mutant form inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; TP53 mutant form inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; TP53 protein affects the reaction [Oxaliplatin results in decreased activity of DUT protein]; TP53 protein affects the reaction [Oxaliplatin results in decreased expression of DUT mRNA]; TP53 protein affects the reaction [Oxaliplatin results in decreased expression of DUT protein]; TP53 protein promotes the reaction [Oxaliplatin results in increased expression of CDKN1A protein] | PMID:16227409 PMID:19015155 PMID:19728331 PMID:19735649 PMID:20708607 | | ||||||||||||||||||||||
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