An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID:
MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Benzo(a)pyrene results in increased expression of TP53 mRNA; Benzo(a)pyrene results in increased expression of TP53 protein; Benzo(a)pyrene results in increased expression of TP53 protein modified form
[Benzo(a)pyrene results in increased mutagenesis of TP53 gene] which affects the folding of TP53 protein; [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of TP53 mRNA; [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of TP53 protein; [TNF protein co-treated with Benzo(a)pyrene] results in increased phosphorylation of TP53 protein; Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of TP53 protein; Roscovitine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 mRNA]; Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of TP53 protein]
Benzo(a)pyrene affects the expression of TP53; Benzo(a)pyrene affects the expression of TP53 mRNA; Benzo(a)pyrene affects the expression of TP53 mutant form
Benzo(a)pyrene metabolite results in increased expression of TRP53 protein modified form; Benzo(a)pyrene results in increased expression of TP53 mRNA; Benzo(a)pyrene results in increased expression of TRP53 mRNA; Benzo(a)pyrene results in increased expression of TRP53 protein
Benzo(a)pyrene metabolite results in increased expression of TP53 protein; Benzo(a)pyrene results in increased expression of TP53 mRNA; Benzo(a)pyrene results in increased expression of TP53 protein; Benzo(a)pyrene results in increased expression of TP53 protein modified form
[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TRP53 mRNA; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; [XPA gene mutant form co-treated with TRP53 gene mutant form] affects the susceptibility to Benzo(a)pyrene; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene affects the localization of TRP53 protein]; benz(a)anthracene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]; Benzo(a)pyrene promotes the reaction [TRP53 protein binds to FMO3 5' UTR]; Benzo(a)pyrene results in increased expression of and results in increased activity of TRP53 protein; chrysene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; epicatechin gallate promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]; epigallocatechin gallate promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]; fluoranthene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]; fluoranthene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]; fluoranthene promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; naphthacene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in decreased expression of TRP53 mRNA]; Plant Extracts inhibits the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]; thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of TP53 protein]; TRP53 results in increased susceptibility to [Benzo(a)pyrene co-treated with fluoranthene]
2,4,4'-trichlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased expression of TP53 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Benzo(a)pyrene affects the localization of and results in increased expression of TP53 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased expression of TP53 protein]; 2,4,5,2',5'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene affects the localization of TP53 protein]; 2,4,5,2',5'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased expression of TP53 protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene affects the localization of TP53 protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased expression of TP53 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased expression of TP53 protein modified form; [CYP1B1 protein results in increased metabolism of Benzo(a)pyrene] which results in increased expression of TP53 protein modified form; [TP53 protein affects the susceptibility to Benzo(a)pyrene] which affects the chemical synthesis of 13-hydroxyellipticine; [TP53 protein affects the susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; [TP53 protein affects the susceptibility to Benzo(a)pyrene] which results in increased expression of CYP1A1 protein; [TP53 protein binds to CYP1A1 promoter] affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Acrolein inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; Benzo(a)pyrene affects the localization of and results in increased expression of TP53 protein; Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]; Benzo(a)pyrene promotes the reaction [TP53 protein results in increased expression of CYP2A6 mRNA]; Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of TP53 protein; Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein; Benzo(a)pyrene results in increased phosphorylation of and results in increased expression of TP53 protein; Cadmium Chloride affects the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Estradiol promotes the reaction [Benzo(a)pyrene affects the localization of and results in increased expression of TP53 protein]; fluoranthene promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]]; FOXO3 mutant form promotes the reaction [Benzo(a)pyrene affects the localization of TP53 protein]; MDM2 mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; Nitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; Okadaic Acid affects the reaction [Estradiol promotes the reaction [Benzo(a)pyrene affects the localization of TP53 protein]]; Okadaic Acid affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]]; Okadaic Acid inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Benzo(a)pyrene affects the localization of TP53 protein]]; Okadaic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene affects the localization of TP53 protein]]; Okadaic Acid promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]]; PARG affects the reaction [Benzo(a)pyrene results in increased expression of TP53 mRNA]; PARG affects the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]; Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene affects the localization of and results in increased expression of TP53 protein]; TP53 affects the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [Benzo(a)pyrene results in increased expression of MDM2 mRNA]; TP53 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; TP53 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of CGB3 mRNA]; TP53 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]; TP53 protein affects the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TP53 protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]; TP53 protein promotes the reaction [[ellipticine results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Benzo(a)pyrene results in decreased expression of BRCA1 mRNA]; TP53 protein promotes the reaction [ellipticine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; Vitamin E inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Vitamin E inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]
