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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTD[Genistein co-treated with vinclozolin] results in decreased expression of TP53 mRNAPMID:32827888
Tp53decreases expressionISOTrp53 (Mus musculus)6480464CTDGenistein results in decreased expression of TRP53 mRNAPMID:31593742
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDGenistein results in increased expression of TP53 proteinPMID:19800779
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 protein results in increased susceptibility to GenisteinPMID:26768552
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Fluorouracil co-treated with Genistein] results in increased expression of TP53 mRNA; [Genistein co-treated with trichostatin A] results in increased expression of TP53 protein; anacardic acid inhibits the reaction [Genistein promotes the reaction [trichostatin A results in increased acetylation of TP53 protein]]; ATM protein affects the reaction [Genistein results in increased expression of and results in increased phosphorylation of TP53 protein]; EP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]]; EP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 protein]]; Genistein promotes the reaction [Fluorouracil results in increased expression of TP53 protein]; Genistein promotes the reaction [trichostatin A results in increased expression of and results in increased acetylation of TP53 protein]; Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]; Genistein results in increased expression of and results in increased phosphorylation of TP53 proteinPMID:15177039 PMID:15896711 PMID:22626855 PMID:26768552
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