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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53decreases expressionEXP 6480464CTDResveratrol results in decreased expression of TP53 mRNA; Resveratrol results in decreased expression of TP53 proteinPMID:23792339 PMID:33775663
Tp53increases expressionEXP 6480464CTDresveratrol results in increased expression of TP53 protein; resveratrol results in increased expression of TP53 protein modified formPMID:20797428 PMID:20972827
Tp53increases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of TP53 proteinPMID:17984113
Tp53multiple interactionsEXP 6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased acetylation of TP53 protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of TP53 mRNA]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of TP53 protein]; Resveratrol inhibits the reaction [Fenitrothion results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [Methylnitronitrosoguanidine results in increased acetylation of TP53 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of TP53 protein]; TP53 protein promotes the reaction [Resveratrol results in increased expression of CDKN1A mRNA]PMID:17147953 PMID:17984113 PMID:20797428 PMID:23792339 PMID:24492640 PMID:24894866 PMID:34968465 PMID:36493885
Tp53affects expressionISOTrp53 (Mus musculus)6480464CTDresveratrol affects the expression of TRP53 mRNAPMID:16369916
Tp53affects expressionISOTP53 (Homo sapiens)6480464CTDresveratrol affects the expression of TP53 proteinPMID:11522280
Tp53affects localizationISOTP53 (Homo sapiens)6480464CTDresveratrol affects the localization of TP53 proteinPMID:18446786 PMID:24587049
Tp53affects response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 affects the susceptibility to resveratrolPMID:18497562 PMID:19846903
Tp53decreases acetylationISOTrp53 (Mus musculus)6480464CTDresveratrol results in decreased acetylation of TRP53 proteinPMID:17581637 PMID:23129026 PMID:24040102
Tp53decreases activityISOTP53 (Homo sapiens)6480464CTDresveratrol results in decreased activity of TP53 proteinPMID:22252971 PMID:25956474
Tp53decreases expressionISOTrp53 (Mus musculus)6480464CTDresveratrol results in decreased expression of TRP53 proteinPMID:16369916
Tp53increases acetylationISOTrp53 (Mus musculus)6480464CTDresveratrol results in increased acetylation of TP53 proteinPMID:25533949
Tp53increases activityISOTrp53 (Mus musculus)6480464CTDresveratrol results in increased activity of TRP53 proteinPMID:12687016
Tp53increases activityISOTP53 (Homo sapiens)6480464CTDResveratrol results in increased activity of TP53 proteinPMID:20504360 PMID:21740780
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDresveratrol results in increased expression of TRP53 proteinPMID:15122319 PMID:25505154
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTD[Resveratrol results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Resveratrol analog results in increased expression of TP53 protein; Resveratrol metabolite results in increased expression of TP53 protein; Resveratrol results in increased expression of TP53; Resveratrol results in increased expression of TP53 mRNA; Resveratrol results in increased expression of TP53 protein; Resveratrol results in increased expression of TP53 protein modified formPMID:11889192 PMID:11895857 PMID:15149879 PMID:15993843 PMID:16091005 PMID:16209266 PMID:16759640 PMID:17007014 PMID:17050787 PMID:17088997 PMID:17261084 PMID:18089832 PMID:18347188 PMID:19800779 PMID:19846903 PMID:21743969 PMID:22029423 PMID:23152798 PMID:25242450 PMID:25436977 PMID:25776512 PMID:25895606 PMID:26341291 PMID:26911335 PMID:26969377 PMID:26970359 PMID:29242151 PMID:29274324 PMID:29705353
Tp53increases phosphorylationISOTP53 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of TP53 proteinPMID:16790523 PMID:16814113 PMID:16928824 PMID:18222423 PMID:23495037 PMID:23651583 PMID:24933654 PMID:25311616 PMID:29242151
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 protein results in increased susceptibility to resveratrolPMID:11889192 PMID:16518869 PMID:23152798
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one inhibits the reaction [Resveratrol results in increased acetylation of TP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased stability of TRP53 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with Resveratrol] affects the acetylation of TRP53 protein; [Resveratrol results in increased activity of MAPK8 protein] which results in increased phosphorylation of and results in increased activity of TRP53 protein; [Resveratrol results in increased activity of MAPK9 protein] which results in increased phosphorylation of and results in increased activity of TRP53 protein; [Resveratrol results in increased phosphorylation of TRP53 protein] inhibits the reaction [TRP53 protein binds to MDM2 protein]; MAPK1 protein promotes the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of TRP53 protein]; MAPK3 protein promotes the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; Resveratrol inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; Resveratrol inhibits the reaction [Antimycin A results in increased acetylation of TRP53 protein]; Resveratrol inhibits the reaction [CDK5R1 protein results in increased expression of and results in increased acetylation of TRP53 protein]; Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; Resveratrol inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TRP53 protein]; Resveratrol promotes the reaction [MAPK1 protein binds to TRP53 protein]; Resveratrol promotes the reaction [MAPK3 protein binds to TRP53 protein]; Resveratrol promotes the reaction [SIRT1 protein results in increased acetylation of TRP53 protein]; Resveratrol results in increased phosphorylation of and results in increased stability of and results in increased activity of TRP53 protein; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]PMID:11245472 PMID:11933078 PMID:17581637 PMID:19819963 PMID:21593185 PMID:22763982 PMID:24040102 PMID:24885036 PMID:25440059 PMID:25533949 PMID:25665036 PMID:25956474
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [TP53 protein results in increased susceptibility to Resveratrol]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol affects the localization of TP53 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol promotes the reaction [PTGS2 protein binds to TP53 protein modified form]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of TP53 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of TP53 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of TP53 protein]]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TP53 protein]]; [[Resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]] which results in increased acetylation of and results in increased activity of TP53 protein; [[Resveratrol results in increased activity of and results in increased phosphorylation of SIRT1 protein] which co-treated with NAD] results in decreased acetylation of TP53 protein; [Doxorubicin co-treated with Resveratrol] results in increased expression of TP53 mRNA; [Doxorubicin co-treated with Resveratrol] results in increased expression of TP53 protein; [ITGA5 protein binds to ITGB3 protein] promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Resveratrol results in increased activity of TP53 protein]; [Raloxifene Hydrochloride co-treated with Resveratrol] results in increased expression of TP53 mRNA; [Resveratrol affects the localization of PTGS2 protein] which results in increased activity of TP53 protein; [Resveratrol co-treated with AICA ribonucleotide] inhibits the reaction [Glucose results in increased expression of TP53 protein]; [Resveratrol co-treated with Clofarabine] affects the localization of TP53 protein modified form; [Resveratrol co-treated with Clofarabine] results in increased expression of and results in increased activity of TP53 protein modified form; [Resveratrol results in increased acetylation of and results in increased activity of TP53 protein] promotes the reaction [TP53 protein binds to BAX promoter]; [Resveratrol results in increased acetylation of and results in increased activity of TP53 protein] promotes the reaction [TP53 protein binds to CDKN1A promoter]; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein] which results in increased expression of CDKN1A mRNA; [Resveratrol results in increased expression of TP53] promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15]; [Resveratrol results in increased phosphorylation of TP53 protein] which results in increased expression of BAX protein; [Resveratrol results in increased phosphorylation of TP53 protein] which results in increased expression of CDKN1A protein; arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to TP53 protein]]; Bleomycin promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Capsaicin promotes the reaction [Resveratrol results in increased expression of TP53 protein]; EGF protein inhibits the reaction [Resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]; EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of TP53 protein]; HRAS protein promotes the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; HRAS protein promotes the reaction [Resveratrol results in increased expression of TP53 mRNA]; HRAS protein promotes the reaction [TP53 protein results in increased susceptibility to Resveratrol]; Hydrogen Peroxide promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; MRK 003 inhibits the reaction [Resveratrol results in increased expression of TP53]; MTA1 protein inhibits the reaction [Resveratrol results in increased acetylation of TP53 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Resveratrol results in increased expression of TP53 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; PARP1 protein affects the reaction [Resveratrol results in increased acetylation of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; PRKCA protein affects the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; Resveratrol inhibits the reaction [cudraflavone B results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [Glucose affects the localization of TP53 protein]; Resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of TP53 mRNA]; Resveratrol inhibits the reaction [Glucose results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [Palmitates results in increased acetylation of TP53 protein]; Resveratrol inhibits the reaction [Rotenone promotes the reaction [TP53 protein modified form binds to SIRT1 protein]]; Resveratrol inhibits the reaction [Rotenone results in increased expression of TP53 mRNA]; Resveratrol inhibits the reaction [Rotenone results in increased expression of TP53 protein modified form]; Resveratrol inhibits the reaction [Rotenone results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [TNF protein results in increased acetylation of TP53 protein]; Resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]; Resveratrol promotes the reaction [[LMNA protein binds to and results in increased activity of SIRT1 protein] which results in decreased acetylation of TP53 protein]; Resveratrol promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]; Resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of TP53 protein]; Resveratrol promotes the reaction [Capsaicin results in increased expression of TP53 protein]; Resveratrol promotes the reaction [Ceramides results in increased phosphorylation of TP53 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of TP53 protein]; Resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TP53 protein]; Resveratrol promotes the reaction [PML protein binds to TP53 protein]; Resveratrol promotes the reaction [PTGS2 protein binds to TP53 protein modified form]; Resveratrol promotes the reaction [TP53 protein binds to BECN1 protein]; Resveratrol promotes the reaction [TP53 protein binds to CDKN1A promoter]; Resveratrol promotes the reaction [TP53 protein binds to PML protein binds to CREBBP protein]; Resveratrol results in increased acetylation of and results in increased activity of TP53 protein; Resveratrol results in increased acetylation of and results in increased phosphorylation of TP53 protein; Resveratrol results in increased activity of and results in increased acetylation of TP53 protein; Resveratrol results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein; Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein; Resveratrol results in increased phosphorylation of and results in increased activity of TP53 protein; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased acetylation of TP53 protein]]; SIRT1 protein inhibits the reaction [Resveratrol results in increased acetylation of TP53 protein]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitates results in increased acetylation of TP53 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [Resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; Staurosporine promotes the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; SUMO1 protein affects the reaction [Resveratrol results in increased expression of TP53 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and affects the localization of TP53 protein]; TP53 affects the reaction [Capsaicin promotes the reaction [Resveratrol results in increased expression of NOS2 protein]]; TP53 affects the reaction [Capsaicin promotes the reaction [Resveratrol results in increased expression of NOS3 protein]]; TP53 affects the reaction [Resveratrol affects the reaction [Fluorouracil results in increased activity of CASP6 protein]]; TP53 affects the reaction [Resveratrol promotes the reaction [Capsaicin results in increased expression of NOS2 protein]]; TP53 affects the reaction [Resveratrol promotes the reaction [Capsaicin results in increased expression of NOS3 protein]]; TP53 affects the reaction [Resveratrol results in decreased expression of MDM2 protein]; TP53 affects the reaction [Resveratrol results in increased activity of CASP6 protein]; TP53 affects the reaction [Resveratrol results in increased expression of BAX protein]; TP53 affects the reaction [Resveratrol results in increased expression of NOS1 protein]; TP53 affects the reaction [Resveratrol results in increased expression of NOS3 protein]; TP53 mutant form inhibits the reaction [Resveratrol results in decreased expression of NANOG protein]; TP53 protein affects the susceptibility to [Resveratrol co-treated with Clofarabine]; TP53 protein promotes the reaction [Resveratrol promotes the reaction [CASP6 protein results in increased cleavage of LMNA protein]]; TP53 protein promotes the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; Vorinostat promotes the reaction [Resveratrol results in increased acetylation of TP53 protein]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; YARS1 protein affects the reaction [Resveratrol results in increased acetylation of TP53 protein]PMID:11889192 PMID:11895857 PMID:12131363 PMID:15542774 PMID:16518869 PMID:16790523 PMID:16814113 PMID:16928824 PMID:17534123 PMID:17868649 PMID:17959154 PMID:18222423 PMID:18446786 PMID:18497562 PMID:18681908 PMID:19559722 PMID:19631782 PMID:19810103 PMID:19846903 PMID:20068143 PMID:21743969 PMID:23088850 PMID:23152798 PMID:23217256 PMID:23257246 PMID:23495037 PMID:23651583 PMID:23859249 PMID:23881456 PMID:24218232 PMID:24239893 PMID:24603648 PMID:24933654 PMID:25533949 PMID:25895606 PMID:25991017 PMID:26188290 PMID:26969377 PMID:27049278 PMID:29242151 PMID:29705353 PMID:34216621
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