GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 150537096 | RGD | Actinomycin D inhibits the reaction [Sunitinib increases expression of TP53 mRNA and protein in breast epithelium] | | Tp53 | increases activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Dactinomycin results in increased activity of TP53 protein | PMID:12869419 PMID:20655369 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Dactinomycin results in increased expression of TP53 protein; Dactinomycin results in increased expression of TP53 protein modified form | PMID:12927789 PMID:17581298 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [TNF protein co-treated with Dactinomycin] results in decreased expression of TP53 protein; Cadmium Chloride inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Cadmium inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein]; Dactinomycin results in increased expression of and affects the localization of TP53 protein; Dactinomycin results in increased expression of and results in increased activity of TP53 protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]] | PMID:10531375 PMID:12807743 PMID:12927789 PMID:16024796 PMID:23968587 | | ||||||||||||||||||||||
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