Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:25255
Term: methyl methanesulfonate
Definition: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.
Chemical ID: MESH:D008741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases activityISOTP53 (Homo sapiens)6480464CTDMethyl Methanesulfonate results in increased activity of TP53 proteinPMID:20655369
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDMethyl Methanesulfonate results in increased expression of TP53 proteinPMID:32087850
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 gene mutant form results in increased susceptibility to Methyl MethanesulfonatePMID:25595616
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDTRP53 protein affects the reaction [Methyl Methanesulfonate results in increased expression of BTG2 mRNA]PMID:22003191
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Folic Acid co-treated with Methyl Methanesulfonate] results in decreased expression of TP53 mRNA; Cadmium Chloride inhibits the reaction [Methyl Methanesulfonate results in increased expression of and results in increased activity of TP53 protein]; Cadmium inhibits the reaction [Methyl Methanesulfonate results in increased expression of and results in increased activity of TP53 protein]; Methyl Methanesulfonate results in increased expression of and results in increased activity of TP53 protein; Methyl Methanesulfonate results in increased phosphorylation of and results in increased activity of TP53 protein; TP53 protein affects the reaction [Methyl Methanesulfonate results in increased expression of CDKN1A mRNA]PMID:10531375 PMID:17079232 PMID:25078064 PMID:30581319
Go Back to source page   Continue to Ontology report