GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | increases activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Methyl Methanesulfonate results in increased activity of TP53 protein | PMID:20655369 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Methyl Methanesulfonate results in increased expression of TP53 protein | PMID:32087850 | Tp53 | increases response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 gene mutant form results in increased susceptibility to Methyl Methanesulfonate | PMID:25595616 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | TRP53 protein affects the reaction [Methyl Methanesulfonate results in increased expression of BTG2 mRNA] | PMID:22003191 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [Folic Acid co-treated with Methyl Methanesulfonate] results in decreased expression of TP53 mRNA; Cadmium Chloride inhibits the reaction [Methyl Methanesulfonate results in increased expression of and results in increased activity of TP53 protein]; Cadmium inhibits the reaction [Methyl Methanesulfonate results in increased expression of and results in increased activity of TP53 protein]; Methyl Methanesulfonate results in increased expression of and results in increased activity of TP53 protein; Methyl Methanesulfonate results in increased phosphorylation of and results in increased activity of TP53 protein; TP53 protein affects the reaction [Methyl Methanesulfonate results in increased expression of CDKN1A mRNA] | PMID:10531375 PMID:17079232 PMID:25078064 PMID:30581319 | |
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