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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:17362
Term: quinoline
Definition: The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring.
Chemical ID: MESH:C037219
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases activityISOTP53 (Homo sapiens)6480464CTDquinoline analog results in increased activity of TP53 proteinPMID:12082016
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTD[quinoline analog results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein; quinoline analog results in increased expression of TP53 protein; quinoline analog results in increased expression of TP53 protein mutant formPMID:18645022
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