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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects expressionEXP 6480464CTDQuercetin affects the expression of TP53 proteinPMID:22000973
Tp53increases expressionEXP 6480464CTDQuercetin results in increased expression of TP53 mRNAPMID:18095365
Tp53multiple interactionsEXP 6480464CTD[1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) co-treated with Quercetin] results in increased expression of TP53 protein; Acetylcysteine inhibits the reaction [Quercetin analog results in decreased phosphorylation of TP53 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Quercetin analog results in decreased phosphorylation of TP53 protein]; Quercetin analog results in increased expression of and results in decreased phosphorylation of TP53 protein; Quercetin inhibits the reaction [aluminum lactate results in increased expression of TP53 protein]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of TP53 mRNA]; Quercetin inhibits the reaction [estradiol 3-benzoate results in increased expression of TP53 protein]; Quercetin inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Quercetin inhibits the reaction [Levetiracetam results in increased activity of TP53 protein]; Quercetin inhibits the reaction [Rotenone results in increased expression of TP53 mRNA]PMID:16647178 PMID:23529952 PMID:23907460 PMID:24316378 PMID:24902966 PMID:26944603 PMID:27525270 PMID:33439051 PMID:35337893 PMID:37098359
Tp53affects expressionISOTP53 (Homo sapiens)6480464CTDQuercetin affects the expression of TP53 mRNAPMID:32530119
Tp53affects localizationISOTrp53 (Mus musculus)6480464CTDQuercetin affects the localization of TRP53 proteinPMID:18813348
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDQuercetin results in decreased expression of TP53 mRNA; Quercetin results in decreased expression of TP53 protein; Quercetin results in decreased expression of TP53 protein mutant formPMID:16720314 PMID:16948901 PMID:23727915 PMID:24849437
Tp53increases acetylationISOTP53 (Homo sapiens)6480464CTDQuercetin results in increased acetylation of TP53 proteinPMID:25896587
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDQuercetin results in increased expression of TRP53 mRNA; Quercetin results in increased expression of TRP53 proteinPMID:25658812 PMID:25862958
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDQuercetin analog results in increased expression of TP53 mRNA; Quercetin analog results in increased expression of TP53 protein; Quercetin results in increased expression of TP53 mRNA; Quercetin results in increased expression of TP53 protein; Quercetin results in increased expression of TP53 protein modified formPMID:14715546 PMID:17973296 PMID:19293639 PMID:19623560 PMID:20803121 PMID:21632981 PMID:21933852 PMID:25289772 PMID:25896587 PMID:26311153 PMID:26341291
Tp53increases phosphorylationISOTP53 (Homo sapiens)6480464CTDQuercetin results in increased phosphorylation of TP53 proteinPMID:22983795
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Quercetin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]; Quercetin inhibits the reaction [TRP53 protein results in increased expression of CDKN1A mRNA]PMID:18813348 PMID:28681665 PMID:34726822
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in decreased expression of TP53 mRNA; [Quercetin analog co-treated with Nickel] results in increased expression of TP53 protein; Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]; MIR34A mRNA affects the reaction [Quercetin results in increased acetylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]; Quercetin inhibits the reaction [KRAS protein affects the activity of TP53 protein]; Quercetin results in decreased degradation of and results in increased stability of TP53 mRNA; Quercetin results in decreased ubiquitination of and results in increased stability of TP53 protein; Quercetin results in increased expression of and affects the localization of TP53 protein; Quercetin results in increased expression of and results in increased phosphorylation of TP53 protein; Quercetin results in increased phosphorylation of and results in increased activity of TP53 protein; Tamoxifen affects the reaction [Quercetin affects the expression of TP53 mRNA]; TP53 protein affects the reaction [Quercetin results in increased expression of MIR34A mRNA]PMID:15177039 PMID:15735102 PMID:15795422 PMID:18323654 PMID:19424582 PMID:20577783 PMID:22983795 PMID:23918355 PMID:25078064 PMID:25108166 PMID:25896587 PMID:27514524 PMID:32530119
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