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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faslgincreases expressionEXP 6480464CTDAcrolein results in increased expression of FASLG mRNAPMID:27238871
Faslgmultiple interactionsEXP 6480464CTDAcrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Acrolein results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]PMID:27238871
Faslgincreases expressionISOFasl (Mus musculus)6480464CTDAcrolein results in increased expression of FASL proteinPMID:24376112
Faslgincreases expressionISOFASLG (Homo sapiens)6480464CTDAcrolein results in increased expression of FASLG mRNAPMID:27238871
Faslgmultiple interactionsISOFasl (Mus musculus)6480464CTDcapsazepine inhibits the reaction [Acrolein results in increased expression of FASL protein]; Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein]PMID:24376112
Faslgmultiple interactionsISOFASLG (Homo sapiens)6480464CTD[Acrolein co-treated with Zidovudine] results in increased expression of FASLG protein; Acrolein promotes the reaction [RELA protein binds to FASLG promoter]; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Acrolein results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]PMID:27238871
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