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GENE - TERM ANNOTATION REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: DOID:9074
Term: systemic lupus erythematosus
Definition: A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnf ISOTNF (Homo sapiens)7245570RGDprotein:increased expression:serum  
Tnf ISOTNF (Homo sapiens)7245571RGDDNA:polymorphisms, haplotype:promoter:multiple (human) 
Tnf ISOTNF (Homo sapiens)155663483RGDmRNA:increased expression:kidney (human) 
Tnf ISOTNF (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Systemic lupus erythematosus, susceptibility toPMID:10450718 PMID:11261930 PMID:11506397 PMID:11826025 PMID:11896460 PMID:12485196 PMID:12746914 PMID:12759288 PMID:14681301 PMID:14718719 PMID:16418737 PMID:16720636 PMID:16865291 PMID:16909270 PMID:18050183 PMID:18713756 PMID:19365401 PMID:22760475 PMID:22992668 PMID:8056188 PMID:9818939
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