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GENE - TERM ANNOTATION REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: DOID:3770
Term: pulmonary fibrosis
Definition: An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. (DO)
Definition Source(s): https://www.sciencedirect.com/science/article/pii/S0954611106004331 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnf ISOTnf (Mus musculus)4142851RGD  
Tnf ISOTnf (Mus musculus)4143417RGD  
Tnf ISOTNF (Homo sapiens)4143258RGDDNA:polymorphism:promoter 
TnftreatmentISOTnf (Mus musculus)2314537RGD  
Tnf ISOTNF (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:11394717 PMID:16324872 PMID:17266442 PMID:25216247 PMID:26368622
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