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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Thra
Name: thyroid hormone receptor alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thradecreases activityISOThra (Mus musculus)6480464CTDLipopolysaccharides results in decreased activity of THRA proteinPMID:12388159
Thradecreases expressionISOThra (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of THRA mRNA; Lipopolysaccharides results in decreased expression of THRA mRNA alternative form; Lipopolysaccharides results in decreased expression of THRA protein; Lipopolysaccharides results in decreased expression of THRA protein alternative formPMID:12057914 PMID:12388159 PMID:16847310 PMID:17641275
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