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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat5b
Name: signal transducer and activator of transcription 5B
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat5bmultiple interactionsISOStat5b (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B protein]; [INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of STAT5B proteinPMID:26972250
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