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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:85990
Term: panobinostat
Definition: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
Chemical ID: MESH:C496932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases acetylationISOSTAT3 (Homo sapiens)6480464CTDPanobinostat results in increased acetylation of STAT3 proteinPMID:26775640
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDPanobinostat inhibits the reaction [STAT3 protein binds to GADD45G promoter]; Panobinostat promotes the reaction [Resveratrol inhibits the reaction [STAT3 protein binds to GADD45G promoter]]; Panobinostat promotes the reaction [SRT2183 inhibits the reaction [STAT3 protein binds to GADD45G promoter]]PMID:23681230
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