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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:8104
Term: phenylpropanolamine
Definition: An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group. A decongestant and appetite suppressant, it is commonly used in prescription and over-the-counter cough and cold preparations.
Chemical ID: MESH:D010665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases activityEXP 6480464CTDPhenylpropanolamine results in increased activity of STAT3 proteinPMID:24792324
Stat3increases expressionEXP 6480464CTDPhenylpropanolamine results in increased expression of STAT3 mRNA; Phenylpropanolamine results in increased expression of STAT3 protein modified formPMID:24792324
Stat3increases response to substanceEXP 6480464CTDSTAT3 mRNA results in increased susceptibility to PhenylpropanolaminePMID:24792324
Stat3multiple interactionsEXP 6480464CTDEnzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 protein modified form]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of CAT mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA]PMID:24792324
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