GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | increases activity | EXP | | 6480464 | CTD | Phenylpropanolamine results in increased activity of STAT3 protein | PMID:24792324 | Stat3 | increases expression | EXP | | 6480464 | CTD | Phenylpropanolamine results in increased expression of STAT3 mRNA; Phenylpropanolamine results in increased expression of STAT3 protein modified form | PMID:24792324 | Stat3 | increases response to substance | EXP | | 6480464 | CTD | STAT3 mRNA results in increased susceptibility to Phenylpropanolamine | PMID:24792324 | Stat3 | multiple interactions | EXP | | 6480464 | CTD | Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 protein modified form]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of CAT mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA] | PMID:24792324 | |
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