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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3affects localizationEXP 6480464CTDPhenylephrine affects the localization of STAT3 proteinPMID:19299911
Stat3increases expressionEXP 6480464CTDPhenylephrine results in increased expression of STAT3PMID:19299911
Stat3multiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]PMID:19299911 PMID:27094369
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