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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]; [Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]; [Methoxychlor affects the activity of ESR2 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]; Methoxychlor promotes the reaction [LIF protein results in increased activity of STAT3 protein]; Tamoxifen inhibits the reaction [[Methoxychlor affects the activity of ESR1 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]]PMID:14975756
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