GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | increases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in increased expression of STAT3 mRNA | PMID:25993096 | Stat3 | affects localization | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Cadmium Chloride affects the localization of STAT3 protein modified form | PMID:19429262 | Stat3 | decreases expression | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in decreased expression of STAT3 protein modified form | PMID:33813002 | Stat3 | increases expression | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased expression of STAT3 mRNA | PMID:23948867 | Stat3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased phosphorylation of STAT3 protein | PMID:23948867 | Stat3 | increases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Cadmium Chloride results in increased phosphorylation of STAT3 protein | PMID:27634459 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [[[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein] promotes the reaction [STAT3 protein binds to STAT3 protein]; [[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in increased phosphorylation of STAT3 protein] which results in increased expression of MT2; [[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein; [[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in increased phosphorylation of STAT3 protein; [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [MAPK1 protein co-treated with MAPK3 protein] affects the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of STAT3 mRNA]; Cadmium Chloride promotes the reaction [EGFR protein binds to STAT3 protein]; Cadmium Chloride promotes the reaction [STAT3 protein binds to SRC protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein; Gefitinib inhibits the reaction [Cadmium Chloride results in increased expression of STAT3 mRNA]; Gefitinib inhibits the reaction [Cadmium Chloride results in increased phosphorylation of STAT3 protein] | PMID:23376140 PMID:23948867 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; Cadmium Chloride inhibits the reaction [CNTF protein affects the localization of STAT3 protein]; Cadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]; Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]; Cadmium Chloride promotes the reaction [ERN1 protein binds to STAT3 protein]; Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein; catalase-polyethylene glycol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; STAT3 protein inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2L1 mRNA]; STAT3 protein inhibits the reaction [Cadmium Chloride results in decreased expression of CCND1 mRNA]; STAT3 protein inhibits the reaction [Cadmium Chloride results in decreased expression of MCL1 mRNA]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] | PMID:16843830 PMID:19429262 PMID:19635391 PMID:33813002 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |