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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases expressionISOStat3 (Mus musculus)6480464CTDMercuric Chloride results in increased expression of STAT3 mRNAPMID:37172713
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDMercuric Chloride analog results in increased phosphorylation of STAT3 protein; Mercuric Chloride results in increased phosphorylation of STAT3 proteinPMID:29981841
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride results in increased phosphorylation of STAT3 protein]PMID:29981841
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]; Ascorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]; Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]; Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]PMID:16896058 PMID:19635391
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