GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | increases expression | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Silicon Dioxide results in increased expression of STAT3 mRNA | PMID:20490462 PMID:23221170 | Stat3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Silicon Dioxide results in increased phosphorylation of STAT3 protein | PMID:30658076 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | [Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA; IL6RA mRNA affects the reaction [Silicon Dioxide results in increased expression of STAT3 mRNA]; MIR125A mRNA inhibits the reaction [Silicon Dioxide results in increased phosphorylation of STAT3 protein] | PMID:20490462 PMID:22155353 PMID:30658076 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; AG 1879 inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein; STAT3 protein promotes the reaction [Silicon Dioxide results in increased expression of PTGS2 protein] | PMID:29894800 | |
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