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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases expressionISOStat3 (Mus musculus)6480464CTDSilicon Dioxide results in increased expression of STAT3 mRNAPMID:20490462 PMID:23221170
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDSilicon Dioxide results in increased phosphorylation of STAT3 proteinPMID:30658076
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTD[Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA; IL6RA mRNA affects the reaction [Silicon Dioxide results in increased expression of STAT3 mRNA]; MIR125A mRNA inhibits the reaction [Silicon Dioxide results in increased phosphorylation of STAT3 protein]PMID:20490462 PMID:22155353 PMID:30658076
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; AG 1879 inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein; STAT3 protein promotes the reaction [Silicon Dioxide results in increased expression of PTGS2 protein]PMID:29894800
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