GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | decreases expression | ISO | Stat3 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of STAT3 mRNA; sodium arsenite results in decreased expression of STAT3 protein modified form | PMID:23143138 PMID:28370166 | Stat3 | decreases expression | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased expression of STAT3 | PMID:17224793 | Stat3 | decreases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased phosphorylation of STAT3 protein | PMID:29039521 | Stat3 | decreases response to substance | ISO | Stat3 (Mus musculus) | 6480464 | CTD | STAT3 protein results in decreased susceptibility to sodium arsenite | PMID:23143138 | Stat3 | increases expression | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of STAT3 mRNA | PMID:28444938 | Stat3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased phosphorylation of STAT3 protein | PMID:20008137 PMID:26631322 | Stat3 | increases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased phosphorylation of STAT3 protein | PMID:26101800 PMID:32890875 PMID:34953898 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; [IL6 protein results in increased activity of STAT3 protein] which results in decreased susceptibility to sodium arsenite; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; Estrogens inhibits the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; SOCS3 mutant form inhibits the reaction [Estrogens inhibits the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]] | PMID:20008137 PMID:23143138 PMID:26631322 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of STAT3 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein; [sodium arsenite results in increased abundance of arsenite] which results in increased phosphorylation of STAT3 protein; CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; Genistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased phosphorylation of STAT3 protein]; IL6 protein promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]]; Lapatinib inhibits the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; METTL3 protein affects the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of STAT3 protein]; METTL3 protein promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]; MIR21 mRNA promotes the reaction [STAT3 protein promotes the reaction [sodium arsenite results in decreased expression of CDH1 protein]]; MIR21 mRNA promotes the reaction [STAT3 protein promotes the reaction [sodium arsenite results in increased expression of VIM protein]]; reparixin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; SOCS3 protein affects the reaction [METTL3 protein affects the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of STAT3 protein]]; sodium arsenite inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; sodium arsenite inhibits the reaction [JAK1 protein results in increased phosphorylation of STAT3 protein]; sodium arsenite promotes the reaction [STAT3 protein binds to CD274 promoter]; sodium arsenite promotes the reaction [STAT3 protein binds to WFDC21P mRNA]; sodium arsenite results in increased expression of and results in increased phosphorylation of STAT3 protein; sodium arsenite results in increased phosphorylation of and affects the localization of STAT3 protein; STAT3 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of MIR21 mRNA]; STAT3 protein affects the reaction [sodium arsenite results in increased expression of KRT1 protein]; STAT3 protein affects the reaction [sodium arsenite results in increased expression of KRT10 protein]; STAT3 protein promotes the reaction [sodium arsenite results in decreased expression of CDH1 protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of BCL2 protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of CCND1 mRNA]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of CCND1 protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of CD274 protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of MIR21 mRNA]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PCNA mRNA]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PCNA protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of VIM protein]; stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]]; WFDC21P mRNA promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein] | PMID:15116095 PMID:23192986 PMID:24004609 PMID:26101800 PMID:28444938 PMID:32890875 PMID:33396024 PMID:34953898 PMID:36368553 | | ||||||||||||||||||||||
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