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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionEXP 6480464CTDRotenone results in decreased expression of STAT3 mRNAPMID:17442543
Stat3increases expressionEXP 6480464CTDRotenone results in increased expression of STAT3 mRNAPMID:28374803
Stat3multiple interactionsEXP 6480464CTDRisperidone inhibits the reaction [Rotenone results in decreased expression of STAT3 mRNA]PMID:17442543
Stat3affects response to substanceISOStat3 (Mus musculus)6480464CTDSTAT3 protein affects the susceptibility to RotenonePMID:20224768
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDRotenone results in decreased expression of STAT3 mRNA; Rotenone results in decreased expression of STAT3 proteinPMID:31408661
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]PMID:15748169 PMID:19635391
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