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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3affects localizationISOSTAT3 (Homo sapiens)6480464CTDDDT affects the localization of STAT3 proteinPMID:24820114
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [DDT results in increased phosphorylation of and results in increased expression of STAT3 protein]; DDT results in increased phosphorylation of and results in increased expression of STAT3 protein; ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein]; WP1066 inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein]PMID:24820114
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