GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Spp1 | decreases expression | ISO | Spp1 (Mus musculus) | 6480464 | CTD | Dexamethasone results in decreased expression of SPP1 mRNA; Dexamethasone results in decreased expression of SPP1 protein | PMID:22733784 PMID:24116280 | Spp1 | increases expression | ISO | SPP1 (Homo sapiens) | 6480464 | CTD | Dexamethasone results in increased expression of SPP1 mRNA | PMID:19853017 | Spp1 | multiple interactions | ISO | Spp1 (Mus musculus) | 6480464 | CTD | [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SPP1 mRNA; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SPP1 mRNA]; Plant Extracts inhibits the reaction [Dexamethasone results in decreased expression of SPP1 protein] | PMID:24116280 PMID:26492236 | Spp1 | multiple interactions | ISO | SPP1 (Homo sapiens) | 6480464 | CTD | [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of SPP1 mRNA; [SAG compound co-treated with 2,4-di-tert-butylphenol co-treated with Fibroblast Growth Factor 2 co-treated with Ascorbic Acid co-treated with alpha-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA; PARG mRNA inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid co-treated with Cholecalciferol] results in increased expression of SPP1 mRNA] | PMID:22940495 PMID:36682590 | |
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