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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:30742
Term: ethylene glycol
Definition: A 1,2-glycol compound produced via reaction of ethylene oxide with water.
Chemical ID: MESH:D019855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1increases expressionEXP 6480464CTDEthylene Glycol results in increased expression of SPP1 mRNA; Ethylene Glycol results in increased expression of SPP1 proteinPMID:24145091 PMID:27018375 PMID:27241030 PMID:37244400
Spp1multiple interactionsEXP 6480464CTD[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]PMID:27018375 PMID:27241030 PMID:37414240
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