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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1increases expressionEXP 6480464CTDQuercetin results in increased expression of SPP1 mRNAPMID:26053266
Spp1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of SPP1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of SPP1 mRNA]; [Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNAPMID:23223575 PMID:26053266
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of SPP1 mRNAPMID:20596804
Spp1increases expressionISOSPP1 (Homo sapiens)6480464CTDQuercetin results in increased expression of SPP1 mRNA; Quercetin results in increased expression of SPP1 proteinPMID:16996034 PMID:21632981 PMID:37690812
Spp1multiple interactionsISOSpp1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SPP1 mRNA]PMID:25712622
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