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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:5613
Term: haloperidol
Definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Chemical ID: MESH:D006220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTDHaloperidol results in decreased expression of SOD2 mRNA; Haloperidol results in decreased expression of SOD2 proteinPMID:15860345 PMID:16564057
Sod2multiple interactionsEXP 6480464CTDHaloperidol results in decreased activity of and results in decreased expression of SOD2 proteinPMID:12482469
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