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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects response to substanceEXP 6480464CTDSOD2 protein affects the susceptibility to AcetaminophenPMID:19647030
Sod2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of SOD2 proteinPMID:16538043
Sod2increases expressionEXP 6480464CTDAcetaminophen results in increased expression of SOD2 mRNA; Acetaminophen results in increased expression of SOD2 proteinPMID:12051994 PMID:33387578
Sod2multiple interactionsEXP 6480464CTDAcetaminophen inhibits the reaction [Vitamin K 3 results in increased activity of SOD2 protein]; Hemin promotes the reaction [Acetaminophen results in increased expression of SOD2 protein]; SOD2 protein affects the reaction [Acetaminophen affects the expression of HMOX1 protein]PMID:12051994 PMID:19265712 PMID:19647030
Sod2affects expressionISOSod2 (Mus musculus)6480464CTDAcetaminophen affects the expression of SOD2 mRNAPMID:17562736
Sod2affects expressionISOSOD2 (Homo sapiens)6480464CTDAcetaminophen affects the expression of SOD2 mRNAPMID:25704631
Sod2affects response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 protein affects the susceptibility to AcetaminophenPMID:19332662
Sod2decreases activityISOSod2 (Mus musculus)6480464CTDAcetaminophen results in decreased activity of SOD2 proteinPMID:22683606
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of SOD2 mRNA; Acetaminophen results in decreased expression of SOD2 proteinPMID:30099449 PMID:35166444 PMID:35179299
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of SOD2 mRNAPMID:21420995 PMID:29067470
Sod2decreases response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 protein results in decreased susceptibility to AcetaminophenPMID:21241727
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of SOD2 mRNA; Acetaminophen results in increased expression of SOD2 proteinPMID:21329376 PMID:31077331 PMID:33271250
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of SOD2 mRNAPMID:31059760 PMID:31077331
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDCHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]; naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; Rotenone inhibits the reaction [Acetaminophen results in decreased expression of SOD2 mRNA]; Rotenone inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein]; SIRT1 affects the reaction [Acetaminophen results in increased expression of SOD2 mRNA]; SOD2 gene mutant form promotes the reaction [Acetaminophen affects the transport of AIFM1 protein]PMID:21241727 PMID:22683606 PMID:30099449 PMID:31077331 PMID:33271250 PMID:35166444 PMID:35179299
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of SOD2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in increased expression of SOD2 mRNA; SIRT1 affects the reaction [Acetaminophen results in increased expression of SOD2 mRNA]PMID:31059760 PMID:31077331 PMID:33819548
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