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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein polymorphism affects the susceptibility to MethotrexatePMID:25330300
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDMethotrexate results in decreased expression of SOD2 mRNAPMID:19192274
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDMethotrexate results in increased expression of SOD2 proteinPMID:25575725
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDMethotrexate results in increased expression of SOD2 mRNA; Methotrexate results in increased expression of SOD2 proteinPMID:25575725
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]; Methotrexate promotes the reaction [CREB1 protein binds to SOD2 promoter]; PRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]; PRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 protein]; PRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]; PRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 protein]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of BAX mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of BCL2 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of CAT mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of SOD2 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP3 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP3 protein]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 mRNA]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of CASP8 protein]; SOD2 protein polymorphism affects the reaction [Methotrexate results in increased expression of GPX1 mRNA]PMID:25330300 PMID:25575725
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