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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects activityEXP 6480464CTDEmodin affects the activity of SOD2 proteinPMID:23615023
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDEmodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]PMID:21382473
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