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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Mifepristone results in increased expression of SOD2 mRNA]; Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD2 protein]; Verapamil inhibits the reaction [Dexamethasone inhibits the reaction [Paraquat results in increased activity of SOD2 protein]]PMID:17015168 PMID:9038369
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDDexamethasone results in increased expression of SOD2 mRNAPMID:19853017
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SOD2 mRNA; Dexamethasone inhibits the reaction [Mercuric Chloride results in increased expression of SOD2 protein]PMID:16054899 PMID:9374288
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Dexamethasone co-treated with Bortezomib] inhibits the reaction [IL6 protein results in increased expression of SOD2 mRNA]; [Dexamethasone co-treated with Bortezomib] results in decreased expression of SOD2 mRNA; Dexamethasone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]]PMID:23063726 PMID:9038369
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