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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases activityEXP 6480464CTDsodium arsenite results in decreased activity of SOD2 proteinPMID:15804455 PMID:23644418 PMID:23906897 PMID:24184500
Sod2decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of SOD2 mRNA; sodium arsenite results in decreased expression of SOD2 proteinPMID:20122981 PMID:20876158 PMID:21554548 PMID:25764338 PMID:26767369 PMID:29935397
Sod2increases expressionEXP 6480464CTDsodium arsenite results in increased expression of SOD2 mRNA; sodium arsenite results in increased expression of SOD2 proteinPMID:20699118 PMID:29459688
Sod2multiple interactionsEXP 6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of and results in decreased activity of SOD2 protein]; [Calcium co-treated with Zinc] affects the reaction [monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]]; [Calcium co-treated with Zinc] affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SOD2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SOD2 mRNA; Ascorbic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]; Calcium affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]; lead acetate promotes the reaction [sodium arsenite results in decreased activity of SOD2 protein]; monoisoamyl-2,3-dimercaptosuccinate affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in decreased activity of SOD2 protein]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in decreased activity of SOD2 protein]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Plant Extracts inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]; sodium arsenite promotes the reaction [lead acetate results in decreased activity of SOD2 protein]; sodium arsenite results in decreased expression of and results in decreased activity of SOD2 protein; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Zinc affects the reaction [sodium arsenite results in decreased activity of SOD2 protein]PMID:15804455 PMID:20122981 PMID:20876158 PMID:21554548 PMID:23644418 PMID:23906897 PMID:24184500 PMID:26767369 PMID:28225195 PMID:29935397 PMID:33127376 PMID:33171135
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of SOD2 mRNA; sodium arsenite results in decreased expression of SOD2 proteinPMID:17558810 PMID:25979314 PMID:33242462 PMID:33497687
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of SOD2 proteinPMID:34758851
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDsodium arsenite results in increased expression of SOD2 mRNA; sodium arsenite results in increased expression of SOD2 proteinPMID:21396911 PMID:30456849 PMID:30562058 PMID:35679981
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of SOD2 mRNA; sodium arsenite results in increased expression of SOD2 proteinPMID:20473585 PMID:28229933 PMID:34032870 PMID:36958258
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of SOD2 protein; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in increased expression of SOD2 protein; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]; SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to SOD2 promoter]]; SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of SOD2 protein]; SOD2 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; SOD2 protein inhibits the reaction [sodium arsenite results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein modified form]; SOD2 protein inhibits the reaction [sodium arsenite results in increased expression of GADD45A protein]; SOD2 protein inhibits the reaction [sodium arsenite results in increased stability of GADD45A mRNA]; sodium arsenite inhibits the reaction [FOXO3 protein binds to SOD2 promoter]PMID:25561743 PMID:25979314 PMID:31238026 PMID:33242462 PMID:33497687
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SOD2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SOD2 protein; Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]PMID:34758851 PMID:35747940
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