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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:28714
Term: S-butyl-DL-homocysteine (S,R)-sulfoximine
Definition: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Chemical ID: MESH:D019328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in increased susceptibility to Buthionine SulfoximinePMID:15130278 PMID:8877099
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDButhionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]PMID:32585298
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]PMID:10464329
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