GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod2 | decreases activity | EXP | | 6480464 | CTD | Cadmium results in decreased activity of SOD2 protein | PMID:22127830 | Sod2 | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of SOD2 mRNA; Cadmium results in increased expression of SOD2 protein | PMID:21787725 PMID:23916567 PMID:25388156 | Sod2 | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of SOD2 protein; puerarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of SOD2 protein]; SRT1720 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of SOD2 protein] | PMID:36527706 | Sod2 | affects expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Cadmium affects the expression of SOD2 mRNA | PMID:26363317 | Sod2 | decreases expression | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased expression of SOD2 mRNA | PMID:33559965 | Sod2 | increases expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Cadmium results in increased expression of SOD2 protein | PMID:29111403 | Sod2 | multiple interactions | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Cadmium results in increased expression of SOD2 protein]; SOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of STK11 protein] | PMID:21767558 PMID:29111403 | Sod2 | multiple interactions | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD2 mRNA; SOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; SOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein] | PMID:22884995 PMID:35301059 | |
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