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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:18291
Term: manganese atom
Definition: A manganese group element atom that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionEXP 6480464CTDManganese results in increased expression of SOD2 proteinPMID:24787138
Sod2multiple interactionsEXP 6480464CTD2-oxothiazolidine-4-carboxylic acid promotes the reaction [Manganese results in increased expression of SOD2 protein]; Manganese inhibits the reaction [Cadmium Chloride results in decreased activity of SOD2 protein]PMID:12204541 PMID:24787138
Sod2increases activityISOSod2 (Mus musculus)6480464CTDManganese results in increased activity of SOD2 proteinPMID:18317567
Sod2increases activityISOSOD2 (Homo sapiens)6480464CTDManganese results in increased activity of SOD2 proteinPMID:19093460 PMID:27701121
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDManganese deficiency results in increased expression of SOD2 proteinPMID:21312047
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDManganese results in increased expression of SOD2 mRNA; Manganese results in increased expression of SOD2 proteinPMID:17175027
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDParoxetine inhibits the reaction [Manganese deficiency results in increased expression of SOD2 protein]PMID:21312047
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