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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDTretinoin results in increased expression of SOD2 mRNA; Tretinoin results in increased expression of SOD2 proteinPMID:16249480 PMID:17169568 PMID:18280257 PMID:33167477
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[SN50 peptide affects the localization of [RELA protein binds to NFKB1 protein]] inhibits the reaction [Tretinoin results in increased expression of SOD2 protein]; Tretinoin results in increased expression of and results in increased activity of SOD2 proteinPMID:18280257
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