GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Snca | increases expression | EXP | | 6480464 | CTD | manganese chloride results in increased expression of SNCA; manganese chloride results in increased expression of SNCA mRNA; manganese chloride results in increased expression of SNCA protein | PMID:19276553 PMID:23353026 PMID:29289693 | Snca | multiple interactions | EXP | | 6480464 | CTD | Glutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]; Hydrogen Peroxide promotes the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]; manganese chloride promotes the reaction [SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate]]; manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]]; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein]; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased splicing of XBP1 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of ATF4 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of CASP12 protein]; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 protein]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 protein]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 protein]; SNCA protein promotes the reaction [manganese chloride results in increased phosphorylation of ERN1 protein] | PMID:23353026 PMID:23934647 PMID:29289693 | Snca | affects folding | ISO | SNCA (Homo sapiens) | 6480464 | CTD | manganese chloride affects the folding of SNCA protein | PMID:11553618 | Snca | increases expression | ISO | SNCA (Homo sapiens) | 6480464 | CTD | manganese chloride results in increased expression of SNCA mRNA; manganese chloride results in increased expression of SNCA protein | PMID:28986288 PMID:30578841 | Snca | multiple interactions | ISO | SNCA (Homo sapiens) | 6480464 | CTD | [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B mRNA; [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of SNCA protein; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]]; manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]; manganese chloride promotes the reaction [SNCA protein binds to SNCA protein]; manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]]; manganese chloride promotes the reaction [SNCA protein results in increased expression of CSF2 mRNA]; manganese chloride promotes the reaction [SNCA protein results in increased expression of IL6 mRNA]; manganese chloride promotes the reaction [SNCA protein results in increased expression of TNF protein]; SNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]; SNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]; SNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]; SNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]; SNCA gene inhibits the reaction [PDR-1 mutant form results in increased susceptibility to manganese chloride]; SNCA protein inhibits the reaction [manganese chloride affects the localization of CYCS protein]; SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein]; SNCA protein inhibits the reaction [manganese chloride results in increased cleavage of and results in increased activity of PRKCD protein] | PMID:24452053 PMID:25416158 PMID:28539244 PMID:30578841 PMID:32659473 | | ||||||||||||||||||||||
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