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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:30812
Term: iron dichloride
Definition: An iron coordination entity that has formula Cl2Fe.
Chemical ID: MESH:C029451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaaffects foldingISOSNCA (Homo sapiens)6480464CTDferrous chloride affects the folding of SNCA proteinPMID:11553618
Sncaincreases response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA protein mutant form results in increased susceptibility to ferrous chloridePMID:14535945
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTDCytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]PMID:14535945
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