GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc11a2 | decreases metabolic processing | EXP | | 6480464 | CTD | SLC11A2 protein mutant form results in decreased metabolism of Manganese | PMID:17116743 | Slc11a2 | decreases uptake | EXP | | 6480464 | CTD | SLC11A2 protein mutant form results in decreased uptake of Manganese | PMID:17116743 | Slc11a2 | increases abundance | EXP | | 6480464 | CTD | SLC11A2 protein results in increased abundance of Manganese | PMID:25575534 | Slc11a2 | increases expression | EXP | | 6480464 | CTD | Manganese results in increased expression of SLC11A2 mRNA; Manganese results in increased expression of SLC11A2 protein | PMID:16705042 PMID:16729984 PMID:18849539 PMID:19782702 PMID:20224926 PMID:23997110 PMID:25575534 | Slc11a2 | multiple interactions | EXP | | 6480464 | CTD | [[manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [[Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese] which affects the abundance of Copper; [Deferoxamine co-treated with Manganese] results in increased expression of SLC11A2; [manganese chloride results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; [Manganese results in increased expression of SLC11A2 protein] which results in increased abundance of Manganese; Iron inhibits the reaction [SLC11A2 protein results in increased uptake of Manganese]; Manganese promotes the reaction [SLC11A2 protein results in increased transport of Iron]; Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]; SLC11A2 protein affects the reaction [Manganese results in increased transport of Iron] | PMID:11933051 PMID:16729984 PMID:17116743 PMID:18849539 PMID:25575534 | Slc11a2 | increases expression | ISO | SLC11A2 (Homo sapiens) | 6480464 | CTD | Manganese results in increased expression of SLC11A2 mRNA | PMID:17175027 | Slc11a2 | increases uptake | ISO | Slc11a2 (Mus musculus) | 6480464 | CTD | SLC11A2 protein results in increased uptake of Manganese; SLC11A2 results in increased uptake of Manganese | PMID:25772431 PMID:27681840 | Slc11a2 | multiple interactions | ISO | SLC11A2 (Homo sapiens) | 6480464 | CTD | [Deferoxamine results in increased expression of SLC11A2 protein] which results in increased uptake of Manganese; Manganese inhibits the reaction [SLC11A2 protein results in increased transport of Ferrous Compounds] | PMID:22736759 PMID:23764342 | Slc11a2 | multiple interactions | ISO | Slc11a2 (Mus musculus) | 6480464 | CTD | [manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC11A2 mRNA | PMID:34590183 | | ||||||||||||||||||||||
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