GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cxcl12 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of CXCL12 mRNA | PMID:32145629 | Cxcl12 | affects expression | ISO | CXCL12 (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of CXCL12 mRNA | PMID:22574217 | Cxcl12 | affects response to substance | ISO | CXCL12 (Homo sapiens) | 6480464 | CTD | CXCL12 mRNA affects the susceptibility to Estradiol | PMID:22549810 | Cxcl12 | decreases expression | ISO | CXCL12 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of CXCL12 mRNA | PMID:17984146 | Cxcl12 | increases expression | ISO | CXCL12 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of CXCL12 mRNA; Estradiol results in increased expression of CXCL12 protein | PMID:15913882 PMID:15986123 PMID:17555868 PMID:17872378 PMID:18556351 PMID:18692832 PMID:19584281 PMID:19619570 PMID:19797619 PMID:21185374 PMID:22549810 PMID:22643241 PMID:23384675 PMID:24015267 PMID:24758408 PMID:26865669 PMID:27368154 PMID:28396216 PMID:28711546 PMID:31614463 | Cxcl12 | increases secretion | ISO | CXCL12 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased secretion of CXCL12 protein | PMID:20549624 | Cxcl12 | multiple interactions | ISO | Cxcl12 (Mus musculus) | 6480464 | CTD | [Estradiol co-treated with Progesterone] results in increased expression of CXCL12 mRNA | PMID:18556351 | Cxcl12 | multiple interactions | ISO | CXCL12 (Homo sapiens) | 6480464 | CTD | 4-fluorobenzoyl-TN-14003 inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; [Estradiol co-treated with EGF protein] results in increased expression of CXCL12 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of CXCL12 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CXCL12 mRNA; afimoxifene inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL12 protein]; glyceollin inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; Glyphosate promotes the reaction [Estradiol results in decreased expression of CXCL12 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]; Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CXCL12 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA] | PMID:17872378 PMID:17984146 PMID:19584281 PMID:19619570 PMID:19797619 PMID:20549624 PMID:20660070 PMID:21185374 PMID:22549810 PMID:23384675 PMID:24758408 | | ||||||||||||||||||||||
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