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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3639
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scnn1a
Name: sodium channel epithelial 1 subunit alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scnn1adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SCNN1A mRNAPMID:32109520
Scnn1aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SCNN1A mRNAPMID:33387578
Scnn1aaffects expressionISOScnn1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SCNN1A mRNAPMID:21570461
Scnn1aincreases expressionISOSCNN1A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of SCNN1A mRNAPMID:19619570 PMID:20106945 PMID:21632981
Scnn1amultiple interactionsISOScnn1a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of SCNN1A mRNAPMID:16214954
Scnn1amultiple interactionsISOSCNN1A (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SCNN1A mRNAPMID:19619570
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