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GENE - TERM ANNOTATION REPORT

RGD ID: 3637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn5a
Name: sodium voltage-gated channel alpha subunit 5
Acc ID: DOID:0060224
Term: atrial fibrillation
Definition: A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Atrial_fibrillation "DO" "DO", http://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/basics/definition/con-20027014 "DO" "DO", http://www.nhlbi.nih.gov/health/health-topics/topics/af "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn5a ISOSCN5A (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:20062060 PMID:30061737
Scn5a ISOSCN5A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Atrial fibrillationPMID:10807545 PMID:11901046 PMID:14967853 PMID:15176425 PMID:15851227 PMID:15992732 PMID:15996170 PMID:16379539 PMID:17210839 PMID:17210841 PMID:17587741 PMID:18088563 PMID:18378609 PMID:18426444 PMID:18929244 PMID:19026623 PMID:19167345 PMID:19716085 PMID:19808477 PMID:19841300 PMID:20129283 PMID:20636320 PMID:21109022 PMID:21143119 PMID:21167004 PMID:21321465 PMID:22378279 PMID:22581653 PMID:22677073 PMID:22685113 PMID:22995991 PMID:23174487 PMID:23414114 PMID:23465283 PMID:23571586 PMID:23631430 PMID:23861362 PMID:24033266 PMID:24055113 PMID:24317018 PMID:24631775 PMID:24784157 PMID:25410959 PMID:25637381 PMID:25650408 PMID:25741868 PMID:25904541 PMID:26467025 PMID:27153395 PMID:27381756 PMID:27711072 PMID:28086167 PMID:28087566 PMID:28150151 PMID:28202948 PMID:28341781 PMID:28492532 PMID:29247119 PMID:29449639 PMID:29709244 PMID:30086531 PMID:30193851 PMID:30847666 PMID:31231243 PMID:32048431 PMID:32826072 PMID:32893267 PMID:32917565 PMID:33712541 PMID:33919104 PMID:34019817 PMID:34758253 PMID:36129056 PMID:37432518
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