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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3624
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atxn1
Name: ataxin 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atxn1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ATXN1 mRNAPMID:32109520
Atxn1affects expressionISOAtxn1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ATXN1 mRNAPMID:21570461 PMID:24680724 PMID:26377647
Atxn1increases expressionISOAtxn1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ATXN1 mRNAPMID:19933214 PMID:20819909 PMID:25975270
Atxn1increases expressionISOATXN1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ATXN1 mRNAPMID:19619570 PMID:20106945 PMID:21632981 PMID:22903824
Atxn1multiple interactionsISOAtxn1 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of ATXN1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ATXN1 gene]PMID:20819909 PMID:21762485 PMID:25975270
Atxn1multiple interactionsISOATXN1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ATXN1 mRNAPMID:19619570
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