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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3615
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100b
Name: S100 calcium binding protein B
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100bmultiple interactionsISOS100B (Homo sapiens)6480464CTDQuercetin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]; Quercetin inhibits the reaction [S100B protein results in increased expression of CCL2 mRNA]; Quercetin inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA]; Quercetin inhibits the reaction [S100B protein results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]; Quercetin inhibits the reaction [S100B protein results in increased expression of MAPK1 protein]; Quercetin inhibits the reaction [S100B protein results in increased expression of MAPK3 protein]; Quercetin inhibits the reaction [S100B protein results in increased expression of NCF1 protein]; Quercetin inhibits the reaction [S100B protein results in increased expression of PECAM1 mRNA]; Quercetin inhibits the reaction [S100B protein results in increased expression of PTGS2 mRNA]; Quercetin inhibits the reaction [S100B protein results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [S100B protein results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [S100B protein results in increased phosphorylation of MAPK3 protein]PMID:17103373
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