GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rxra | increases expression | EXP | | 6480464 | CTD | pirinixic acid results in increased expression of RXRA mRNA | PMID:22112501 | Rxra | multiple interactions | EXP | | 6480464 | CTD | [[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [pirinixic acid co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA | PMID:20368269 | Rxra | increases activity | ISO | RXRA (Homo sapiens) | 6480464 | CTD | pirinixic acid results in increased activity of RXRA protein | PMID:26135921 | Rxra | increases response to substance | ISO | Rxra (Mus musculus) | 6480464 | CTD | RXRA protein results in increased susceptibility to pirinixic acid | PMID:19176532 | Rxra | multiple interactions | ISO | Rxra (Mus musculus) | 6480464 | CTD | pirinixic acid promotes the reaction [[PPARA protein co-treated with RXRA protein] results in increased expression of IL1RN mRNA]; pirinixic acid results in increased activity of [PPARD protein co-treated with RXRA protein]; pirinixic acid results in increased activity of [PPARG protein co-treated with RXRA protein]; pirinixic acid results in increased activity of [RXRA protein binds to PPARA protein]; RXRA protein affects the reaction [pirinixic acid results in increased expression of ABCC3 mRNA]; RXRA protein inhibits the reaction [pirinixic acid results in decreased expression of SLCO1A1 mRNA]; RXRA protein inhibits the reaction [pirinixic acid results in increased expression of CYP3A11 mRNA]; RXRA protein inhibits the reaction [pirinixic acid results in increased expression of CYP3A11 protein]; RXRA protein inhibits the reaction [pirinixic acid results in increased expression of NR0B2 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in decreased expression of WEE1 protein]; RXRA protein promotes the reaction [pirinixic acid results in increased abundance of Bile Acids and Salts]; RXRA protein promotes the reaction [pirinixic acid results in increased activity of PPARA protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of ACOX1 protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of ALPL protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCNA2 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCNB1 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCND1 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCND1 protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCND3 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCND3 protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CDK1 mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of CDK1 protein]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of IL1B mRNA]; RXRA protein promotes the reaction [pirinixic acid results in increased expression of PCNA protein] | PMID:15997096 PMID:17321000 PMID:19176532 PMID:8700121 | Rxra | multiple interactions | ISO | RXRA (Homo sapiens) | 6480464 | CTD | [pirinixic acid co-treated with alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA | PMID:16292757 | | ||||||||||||||||||||||
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